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Finally, there is no evidence in humans that exogenous lipoic acid can be 'activated' with ATP or GTP and incorporated into lipoic acid-dependent enzymes by a lipoyl transferase (14)

We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis

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They are not coated with polyethylene glycol (PEG), which results in lower bioavailability compared to other well-established and emerging PEGylated liposomal formulations [70]

Nevertheless, deficient levels of folate or B 12 were found in 11.2% and 30.3% of children and adolescents with depressive disorders, while neither deficiency was found in HC [23]