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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

NGF primarily supports small-fiber sensory neurons, the exact neurons damaged in the most common forms of neuropathy

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Rather, it reflects the evidence available, how the compound is manufactured and distributed, and whether regulators believe it should be available through established medical channels