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The low molecular weight peptides (~10 kDa) can cross the blood-brain barrier, theoretically delivering neurotrophic support directly to neurons

Ruxolitinib, a JAK1/2 tyrosine kinase inhibitor approved for myelofibrosis, reverses GPX4 downregulation in TBI and mitigates neurodegeneration, cerebral edema, motor deficits, memory impairment, and anxiety-like behaviors (231)

Furthermore, they postulated that the controlled inflammatory response may impact melittins anti-fibrotic action in activated HSCs

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