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Moreover, factors such as fluid dynamics, pH, and disease-induced pathological alterations in the brains microenvironment (i.e., changes in enzymatic activity, impairment in vascular function, and inflammation) can significantly influence drug distribution and efficacy (Nance et al., 2022)
A disturbance in microbiota composition has been demonstrated to result in heightened levels of uremic toxins, including IS, PCS, and TMAO, along with a decline in LPS and beneficial short-chain fatty acids
[16] reported that sensitization of mechano-responsive A- and C-fibers did not explain pain behavior 45 min after an incision in the rat hind paw
Importantly, altered Ach levels are linked to neurodegeneration, specifically AD where the disease severity in patients correlates with decreases in cholinergic tone [133]
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