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88 Despite differences in biochemical and pharmacological properties of the five currently approved TNFi, there does not seem to be a clinically meaningful difference between them in terms of efficacy and safety
Continuous use advantages include maintaining peak benefits without decline periods, avoiding the uncertainty of whether improvements will persist after breaks, simplifying routine through consistency, and potentially maximizing cumulative collagen synthesis through sustained stimulation over months to years
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Most human data come from topical skincare research creams and serums reporting firmer skin, smoother fine lines, better elasticity and improved repair