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Moreover, recent work indicates that, unlike cysteine, homocysteine inhibits endothelial and plasma glutathione peroxidase (Chen et al, 2000

They concluded that the esterified GSH derivative was effective in reducing melanin and tyrosinase activity and raised the pheomelanin/eumelanin ratio without affecting cellular viability

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Centers for Disease Control and Prevention, National Center for Health Statistics

In contrast, indicator systems that specifically sense particular redox couples allow real-time observation of redox changes (Gutscher et al., The experimental difficulties to obtain reliable potentials of thiol/disulfide systems prompt further concern to accept these parameters or changes thereof as critical determinants of biological events

2006;136:1652S1659S