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Assuming that the two processes are independent, the final fitting function, including the effect of the collapse, can be calculated simply by the multiplication of a normal dose-response curve without collapse (Eq

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In some embodiments, a concentration of the otoprotectant, wherein the otoprotectant is an antioxidant or an anti-apoptotic agent is in a range of about 0.1 M to about 100 M, about 1 M to about 100 M, about 10 M to about 100 M, or about 50 M to about 100 M