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Log in EVIDENCE Une revue Cochrane 1 rsume deux essais cliniques randomiss (ECR) 2,3 : Dans la premire tude 2 , 38 patients externes ont t randomiss pour recevoir 2 000 mcg de vitamine B12 par jour par voie orale ou 1 000 mcg de vitamine B12 par voie intramusculaire les 1 er , 3 e , 7 e , 10 e , 14 e , 21 e , 30 e , 60 e et 90 e jours

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The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study