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Colon-targeted KPV study Demonstrated that oral, colon-specific KPV therapy effectively reduced inflammation in preclinical models of inflammatory bowel disease

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doi: 10.1007/s00259-024-06775-x 178 RozenblumLDebrouckerTHabertM-OSoretMDesarnaudSLemercierVCet al

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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Zeineldin M., Abdelmegeid M., Barakat R., Ghanem M

Additionally, ketogenic diets, in theory, can also have a similar impact to calorie restriction, by downregulation of IGF-1 and insulin, promoting PI3K inhibition function, and through increased exposure to oxidative stress for the tumour cells [148,149,150]