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As NADH originates from diverse metabolic pathwaysincluding the tricarboxylic acid (TCA) cycle, -oxidation and amino-acid catabolismcomplex I acts as a metabolic control point that couples cellular metabolic flux to electron transport

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Additionally, TGR5 exerts anti-inflammatory effects by inhibiting NF-B-mediated pro-inflammatory cytokine production and modulating NLRP3 inflammasome activation (76)

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Upon pathogen invasion, PRRs ( e.g