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respiratory syncytial virus-targeting mAb IgG1 nirsevimab [Beyfortus] [107] and severe acute respiratory syndrome coronavirus 2-targeting mix of the IgG1 mAbs tixagevimab cilgavimab [Evusheld] [108, 109]) and blocking activation of the complement cascade to treat the autoimmune disease paroxysmal nocturnal hemoglobinuria (anti-C5 IgG2/4 mAb ravulizumab [Ultomiris] containing the amino acid substitutions M428L/N434S (commonly referred to as LS)) [110]