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Non-biodegradable NPs, while beneficial for sustained delivery, may accumulate in tissues and induce dysfunction or inflammation, potentially exacerbating autoimmune pathology [136]

For example, in comparison to healthy controls, a group of patients with chronic low back pain performing a simple visual attention task presented a reduced deactivation in regions of the default mode network

65 This establishes a persistent pro-inflammatory hepatic microenvironment, further exacerbating liver injury

Algethami, F