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external controls and found overlaps between patients and their relatives, highlighting the importance of considering lifestyle and genetic factors [12]

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2.8 Molecular mechanics-generalized born surface area (MM-GBSA) calculations MM-GBSA calculations were performed using two different tools: the Prime module (Schrodinger Release, 2021f) in the Schrdinger Maestro (Schrodinger Release, 2021e) and the fastDRH ( (Wang et al., 2022)

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Selenium-responsive genes Selenium-responsive genes are the genes whose expression patterns are influenced by supplementation with selenium or selenium-containing compounds

Group 1 (58 men) received vitamin E 300 mg orally twice a day