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In this study, we investigated the skin toxicity of several copper compounds using cell-based in vitro tests and evaluated the expression of various cytokines at genomic and proteomic levels to discover irritancy biomarkers suitable for copper compounds

2001 Dec;96(12):3237-46

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GI events (nausea, vomiting, diarrhea) were the dominant safety signal and occurred at rates higher than reported for Phase 2 retatrutide and higher than for comparable dual or mono-agonist trials

It is noteworthy that -Glu-Glu was not detected in the extracellular medium of cultured neurons (not shown)