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Gradual deterioration of renal function leads to ESRD in the 4th to 5th decade, which is the primary cause of death in patients with untreated Fabry disease 9,10

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However, combining them presents challenges, such as balancing effects on glucose metabolism tesamorelin may raise blood sugar, while retatrutide improves glycemic control

This established the mechanistic rationale for NNMT inhibition

Improved sleep architecture is in turn linked with downstream effects on recovery, cognitive consolidation, and metabolic regulation in study models

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