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MEDI7247 is the only ASCT2 antibody-drug conjugate currently in phase I clinical trials (NCT03811652, NCT03106428)
Disruption of circadian rhythms through exposure to LAN appears to trigger a cascade of biological effects, ranging from melatonin suppression and oxidative stress to immune dysregulation, telomere shortening, and epigenetic alterations
Inhibition of glutathione metabolism by BSO decreased the ESCC tumor burden To investigate whether glutathione metabolism contributed to the progression of ESCC development, we treated mice bearing ESCC 20 weeks after initial carcinogen treatment with buthionine sulfoximine (BSO), a commonly used chemical inhibitor of -glutamylcysteine synthetase (-GCS) that decreases tissue glutathione concentrations (Figure 3a)
Blood (2014) 123(10):157485
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