These changes drive T cells toward senescence, a state of irreversible cell cycle arrest accompanied by the senescence-associated secretory phenotype, characterized by inappropriate activation, poorer function and enhanced secretion of proinflammatory cytokines such as IL-6, TNF-, and IFN- (Olivieri et al., 2018
In TME, DON is produced after enzymatic cleavage of JHU083 (Hanaford et al., 2019)
Die Studie von Maquart et al
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