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It does not have FDA approval for any specific indication

Clinical Update 11/18/2012 Caution with Energy Drinks The FDA has released reports showing deaths and other serious adverse events associated with the use of energy drinks like 5-hour Energy

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Personalized training programs based on genetic profiles could potentially be used to identify high-risk individuals and tailor prevention strategies accordingly

doi: 10.1038/srep36617 (2016)

Treadmill exhaustion test As described 64 , mice were acclimated to the treadmill (Columbus Instruments, Exer-6M Open Treadmill) 23 days before the test