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Description

Nature Medicine 21(8):887-894

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Mechanism of Action 5-Amino-1MQ exerts its metabolic effects primarily through competitive inhibition of nicotinamide N-methyltransferase (NNMT), an enzyme belonging to the methyltransferase superfamily that is expressed in multiple tissues including liver, adipose tissue, skeletal muscle, kidney, and brain, with particularly high expression in visceral (abdominal) adipose tissue - the fat depot most strongly associated with metabolic disease

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By inhibiting NNMT, 5-Amino-1MQ may support cellular NAD+ levels, which are critical for mitochondrial function, energy metabolism, and cellular health

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While human data is still emerging, animal research has been compelling: Fat Cell Shrinkage: Mice given 5-Amino-1MQ experienced reductions in fat cell size by as much as 3040%

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Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopenia

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