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Each component is associated in published preclinical literature with distinct mechanistic pathways, and the blend format allows laboratories to prepare all four under matched conditions for parallel single-agent and combined-arm experiments

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Ultimately, the radical chain reactions will be blocked by the antioxidant enzymes superoxide dismutase (SOD) in association with catalase or GPX that determines the complete free radicals scavenging (Winterbourn, 1993)

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