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usually mild-to-moderate and easing over time [1]

Thats a critical distinction

Unlike earlier-generation GHRPs like GHRP-6 or GHRP-2 , Ipamorelin was specifically designed to minimize unwanted hormonal spikes such as cortisol or prolactin two hormones that can interfere with recovery, fat loss, and libido

This approach has little toxicity and an excellent therapeutic index (El Bakary et al., 2020)