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Unfortunately, glutathione is not absorbed well by the body after oral administration, limiting its clinical use in humans

doi: 10.1016/j.freeradbiomed.2010.01.006 101 GiustariniD.TsikasD.ColomboG.MilzaniA.Dalle-DonneI.FantiP.et al

The interactions of lipin-1 with PPAR and PGC-1 leads to increased expression of fatty acid oxidizing genes such as carnitine palmitoyltransferase-1 (CPT-1: encoded by the CPT1A gene), acyl-CoA oxidases (peroxisomal fatty acid oxidation pathway), and medium-chain acyl-CoA dehydrogenase (MCAD: encoded by the ACADM gene)

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Putting the Numbers in Context The beta coefficients from this meta-analysis represent the independent effect of each treatment after controlling for confounding variables