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In the nucleus, NRF2 binds to antioxidant response elements (ARE) in the promoter regions of its target genes, leading to the transcription of genes that mitigate oxidative damage, support cellular redox balance, and enhance survival mechanisms ( 3.1.1.6 p63 p63 is a transcription factor known as a master regulator of epidermal development and keratinocyte (KC) differentiation
& Liu, F.-C
Licorice and its flavonoids inhibit oxidative damage in the liver
When the disease develops into cirrhosis, it is difficult to reverse the patients condition with conventional clinical treatments
Other Whitening Methods While glutathione injections are becoming very popular, especially after the Made in Heaven series and viral reels on Instagram, there are many other skin brightening treatments also
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