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have observed that HIF is highly active under hypoxic conditions and promotes the transcription of the target gene ITGA6 , which, in conjunction with other integrins, is enriched in breast stem cells and promotes the acquisition of MDR phenotypes in breast cancer 48

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Theoretically, the decreased expression of the enzymes involved in homocysteine remethylation to methionine (MS, BHMT) may cause low hepatic concentration of the methyl donor SAM and subsequently hypomethylation of genes in the liver

(3) McGuire FP, Martinez R, Lenz A, Skinner L, Cushman DM

Conversely, naive CD4 + T cells, exhibit increased production of glucose-6-phosphate dehydrogenase (G6PD), which stimulates Th1 and Th17 cell development and intensifies inflammatory responses (150)

PMID: 11918881