[PubMed: 2798244] 176
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392,393 Many of these substances induce widespread changes in astrocyte functions, including loss of functions and dysregulated astrogliosis, which in turn may serve as comorbidities in degenerative conditions such as AD, PD, and others
Injection of CagA into cells through T4SS fimbriae induces cell changes, impairs cell motility, proliferation, apoptosis, and alters cytoskeleton arrangement
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Additionally, elevated levels of sphingomyelins, which promote neuroinflammation and apoptosis, have also been reported in AD patients [55]