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Notably, histological analysis at this time point revealed no significant hepatocyte damage, suggesting that the rapid decrease in hepsin protein levels may primarily result from the activation and subsequent degradation of the hepsin serine protease in response to APAP-induced hepatotoxicity

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( B ) Under conditions of APAP overdose along with iron overload, the excessive cellular free iron reacts with mitochondrial reactive oxygen species (ROS) to induce lipid peroxidation (LPO) of membranes

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This increases and then depletes your glutathione levels

Of 800 detected proteins significantly enriched over control-IPs, 508 matched entries in this curated list (Supplementary Table 1)