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Chemotherapy works by stopping cells from dividing by messing with DNA

Beyond its role in melatonin synthesis, the pineal gland serves as a biological timekeeper, helping to regulate circadian rhythms, internal cycles that influence sleep, hormone secretion, appetite, and body temperature

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10.1016/j.bbamem.2020.183206 17 KammeyerA.LuitenR

The researchers utilized advanced mass spectrometry and RNA-sequencing to map the exact metabolic dysfunctions driving these conditions, uncovering striking evidence of severe oxidative stress and mitochondrial lipid oxidative damage mediated by glutathione peroxidase 4, as documented in the PNAS metabolic study