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Dose relevance and interpretation in a human exposure context A critical challenge in interpreting the real-world relevance of current in vivo evidence on PET MNPs is the very broad range of administered exposure levels across the included studies (Table 3), which are reported using different metrics (e.g., concentrations in exposure media such as drinking water or food, or administered doses normalised to body weight)

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H., Muhammad Shahbaz, H., Ameer, K., Jo, Y., & Kwon, J