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La prise de quantits trop importantes de paractamol (plus de 4 g par jour) durant plusieurs jours peut provoquer des lsions irrversibles du foie qui n'est plus protg par le glutathion et ncessiter une transplantation hpatique

& Yang, N

doi: 10.5114/biolsport.2017.66003, 12

This oxidative damage is evidenced by elevated levels of 8-hydroxydeoxyguanosine, indicating compromised DNA integrity that facilitates mutations in melanoma-related genes like BRAF and loss of tumor-suppressor functions 119