IP3 might then prompt the release of calcium ions (Ca2+) from intracellular reserves, whereas DAG potentially activates protein kinase C (PKC)
This dual capability makes AOD-9604 unusual among peptides
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Its design illustrates a radical peptidomimetic : only two amino acid residues (Tyr-Ile) are preserved from the native peptide, flanked by non-peptide acyl chains to cross biological barriers
A subset of these molecules not only had improved metabolic stability and circulating ty 2 but exhibited excellent in vitro and in vivo activity
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