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10.1186/s42269-019-0221-8 90 ShrivastavaP.VaibhavK.TabassumR.KhanA.IshratT.KhanM

The logic is straightforward: deliver the healing compound directly to the site of the injury for maximum concentration and effect

Exome sequencing of ALS and rare-variant analyses identified loss-of-function mutations in TBK1 (encoding TANK-binding kinase 1) in 13 of 252 familial ALS pedigrees, but not in sporadic ALS (Freischmidt et al., 2015)