Babula JJ, Bui D, Stevenson HL, Watowich SJ, Neelakantan H
Such measures remove the need for long-term administration of cyanocobalamin
When it becomes overactive, it essentially tells your cells to store more fat and burn less energy, while also depleting your valuable NAD+ reserves
What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect
[DOI] [PubMed] [Google Scholar] 34
At first, injections might be given more often
