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Although the existence of mtNOS has been described in mitochondrial fractions from different organs, recent evidence in rat liver mitochondria has questioned the existence of mtNOS, minimizing the contribution of in situ NO generation within mitochondrial to the formation of peroxynitrite (Venkatakrishnan et al., 2009)

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As part of his research, Anisimov also developed analogues of those peptide bioregulators, such as synthetic tetrapeptide epitalon

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