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Laboratory studies demonstrate that FOXO4-DRI effectiveness depends on senescent cell burden, tissue type, and the specific mechanisms maintaining senescent cell viability in different experimental conditions

, Namikawa, K

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Besides, inhibition of HDACs and histone hyperacetylation, the neuroprotective effect of HDACi may also involve multiple mechanisms of action, involving activation of the kinase pathway by extrinsic signals (Hao, 2004) the suppression of pro-apoptotic factors (Kim et al., 2007) or microglialmediated inflammation (Peng et al., 2005), as reported earlier for valproic acid

Role of apamin-sensitive calcium-activated small-conductance potassium currents on the mechanisms of ventricular fibrillation in pacing-induced failing rabbit hearts