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Mitochondrial dysfunction is a prominent feature in ME/CFS (60, 368375)

For example, mitochondrial dysfunction destabilizes lysosomes, amplifying oxidative stress ( 2.2.2 Endoplasmic reticulum: regulator of lipid metabolism and redox homeostasis The ER maintains cellular homeostasis through protein synthesis, lipid metabolism, and calcium storage ( - localized to the ER membranemediates cystine import for GSH synthesis (65)

Loyer P, Cariou S, Glaise D, Bilodeau M, Baffet G, Guguen-Guillouzo C

[Fisher E, McLennan SV, Tada H, et al

If you look at a lot of children who have ADD/ADHD diagnoses, it's not a straightforward inattention, distractibility, hyperactivity

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