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With respect to the cost criterion, the applicant did not provide a complete cost analysis

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Further preclinical studies have demonstrated that acupuncture at Baihui (GV20), Yintang (EX-HN3), and other related acupoints significantly inhibits microglial polarization toward the pro-inflammatory M1 phenotype and reduces the expression of TNF- and IL-1 by suppressing the Toll-like receptor 4 (TLR4)/Myeloid differentiation primary response 88 (MyD88)/NF-B signaling cascade, thereby attenuating neuroinflammation (Jiang et al., 2024)

Russo GL, Spagnuolo C, Russo M, Tedesco I, Moccia S, Cervellera C (2020) Mechanisms of aging and potential role of selected polyphenols in extending healthspan

4E) and DMF treatment increases both NRF2 association and active histone codes at the CBS gene ARE motif (Fig