Peripheral and central inflammation can both stimulate the KYN pathway and trigger TRP metabolism and subsequent synthesis of various TRYCATs, including the toxic NMDAR activator QUIN, 246 which influences glutamate transmission, has a variety of immunomodulatory effects and has both neurotoxic and neuroprotective effects on the CNS
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Cell Microbiol (2015) 17:13145.10.1111/cmi.12343 49 ImaiYKubaKNeelyGGYaghubian-MalhamiRPerkmannTVan LooGet alIdentification of oxidative stress and toll-like receptor 4 signaling as a key pathway of acute lung injury
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EMT modulates the tumor microenvironment (TME) through multiple mechanisms, thereby enhancing the invasiveness of GBM
