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An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways

Peptides covered by either category are likewise prohibited in and out of competition

INTRODUCTION Glutathione (GSH), the major intracellular thiol compound, is a ubiquitous tripeptide produced by most mammalian cells and it is the main mechanism of antioxidant defense against reactive oxygen species (ROS) and electrophiles

How SAMe accesses hepatocytes has not been clarified but it is proven to become rapidly incorporated within cell membrane phospholipids, to influence intracellular SAMe pathways and products and to readily cross into mitochondria

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