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Under oxidative stress conditions, glutathione disulfide (GSSG) and GSH conjugates are exported into the extracellular space for redox homeostasis and detoxification 23

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Real time quantitative PCR Total RNA was isolated using the ReliaPrep RNA Miniprep Systems kit (Promega, Germany) according to the manufacturers instructions

Regulatory role of mitochondria in ferroptosis Mitochondria, semi-autonomous organelles, have unique metabolic mechanisms that allow these organelles to resist ferroptosis [50, 51]