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Key Research Areas Connective Tissue Models Both compounds studied individually in tendon and ligament repair

In the peptide therapy context, AbbVie's Lupron (leuprolide) franchise treating prostate cancer, endometriosis, uterine fibroids, and precocious puberty via GnRH agonism remains a stable legacy contributor, while Botox Therapeutic ($748 million in Q1 2024 alone) constitutes a significant peptide-adjacent revenue stream

The data in Figure 24 confirm this expectation by demonstrating that D-Nle-Cys-Ile-NH-(CH 2 )5-CONH 2 and D-Nle-Tyr-Ile-NH-(CH 2 ) 5 -CONH 2 , which bind HGF with high affinity (Figure 23) and effectively attenuate HGF-dependent processes (Figures 25, 26, 27 ) completely block HGF dimer formation

Pregnant or breastfeeding women should avoid BPC-157, as no studies evaluate its safety in these populations

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Two features of the preclinical dose-response data are particularly relevant for researchers designing studies