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Therefore, when a drug is administered for a longer time, then sulfate ions are depleted from the body

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This can cause both the medication and caffeine to remain longer in the bloodstream, increasing the risk of restlessness, tremors, and other side effects

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[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Micic S., Lalic N., Djordjevic D., Bojanic N., Bogavac-Stanojevic N., Busetto G.M., Virmani A., Agarwal A

Chen et al., 2000)