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When NNMT is overactive, less nicotinamide is available for recycling, and cellular NAD+ levels fall

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However, human clinical trials are limited and hence, this peptide should not be regarded as a treatment for cancer

A 2021 review published in Nutrients found that GLP-1 receptor agonist use was associated with reduced dietary intake of multiple micronutrients including B12, particularly in patients following calorie-restricted eating patterns, supporting the rationale for monitoring B12 status during treatment even in patients without pre-existing deficiency risk factors