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Eur J Endocrinol 171(4):R137R152

From each included study, we extracted detailed information on the type and source of the bioactive compound, targeted cancer types, experimental models used ( in vitro, in vivo , or clinical), elucidated anticancer mechanisms, and any reported clinical efficacy or safety outcomes

Published clinical trials used continuous daily administration for 12-24 weeks without scheduled breaks, establishing this as a viable approach with maintained safety throughout the treatment period