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Another way in which autophagy negatively regulates TBK1 stability is through the autophagy protein ATG4B, which serves as an adaptor for the recruitment of TBK1 to gamma-aminobutyric acid receptor-associated protein (GABARAP) via its LIR motif

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Comprehensive cancer pre-screening represents a crucial component of patient evaluation due to the potential for these peptides to stimulate angiogenesis, which could theoretically promote malignant growth and metastasis

JAK2 engagement

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doi: 10.1105/tpc.105.033589