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[10] [11] [12] [13] [14] Two of the main upstream regulators of FOXO4 activity are phosphoinositide 3- kinase (PI3K) and serine/threonine kinase AKT/PKB

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These include enzymes like superoxide dismutase (SOD), glutathione (GSH), and N-acetylcysteine (NAC), as well as non-enzymatic antioxidants like vitamin A, vitamin E, coenzyme Q10, and essential trace elements (77, 78)

Praud et al [91] found that a high intake of proanthocyanidin is inversely linked to prostate cancer

Consequently, it is difficult to assess exactly how much GSH our bodies require as this amount can differ from person to person and can change from day to day