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Relative expression of the indicated genes was measured with the Applied Biosystems TaqMan Gene Expression Assays with primer/probe sets (Supplementary Table S1), with Glyceraldehyde 3-phosphate dehydrogenase (GADPH) as a reference

Competing Interests Professor Melanie Davies has acted as a consultant/advisor and speaker for Eli Lilly, Novo Nordisk and Sanofi, has attended advisory boards for Abbvie, Amgen, AstraZeneca, Biomea Fusion, Carmot/Roche, Sanofi, Zealand Pharma Regeneron, GSK and EktaH and as a speaker for AstraZeneca and Boehringer Ingelheim

Becerril-Snchez, B

Treatment of diabetic patients-ED with L-carnitine (an antioxidant) and Sildenafil has been found to reduce oxidative monocyte activity and the endothelial dysfunction markers [21]

Dynamic changes in DNA methylation of extrinsic factors seem to have a role in the regulation of neuronal proliferation and survival