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Children received a high-dose multistrain probiotic mixture (De Simone Formulation, 450 billion CFU/day)

This characteristic is particularly significant for treating central nervous system disorders, where systemic drug administration is often ineffective

Although the thioredoxin and glutaredoxin systems are both found in the chloroplast stroma (Rouhier et al., 2008

Additionally, the accumulation of GSSG and depletion of GSH can be directly toxic to cells by activating the SAPK/MAPK apoptotic signaling pathway, which leads to programmed cell death [29,83,98,99]

Indeed, based on evidence from GST activity and RNAi studies, three GSTs are thought to have contributed to the adaptation of N