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Moreover, the pituitaries of sst 2 knockout mice display a higher ACTH release in vitro compared to that of wild type littermates (Viollet et al., 2000) and in vivo , sst 2 knockout mice have elevated basal levels of plasma corticosterone, while those of sst 4 knockout mice were unchanged (Prvt et al., 2 and sst 4 and pituitary sst 2 (Figure 1)

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