When those junctions are compromised, by NSAIDs, alcohol, chronic stress, or repeated antibiotic courses, the result is a low-grade inflammatory state that shows up as bloating, systemic fatigue, food sensitivities, and immune dysregulation
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A 2025 narrative review on BPC-157 published in PMC summarizes the musculoskeletal healing evidence across animal models, noting that the peptide demonstrates accelerated recovery of tendons, ligaments, and connective tissue through these overlapping pathways
Fatigue, mental fog, irritability, and low mood are often brushed off as just stress. But sometimes, the real culprit is something deeper like a vitamin B12 deficiency