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Decoys were obtained from the DUDE package ( 2.4.3.3 Validation of hypothesis ensembles with YN2 To further refine the results and behavior of the ensembles, we introduced a metric called Yassers number two (YN2), which combines the values of ensemble phase score, the number of matching stable conformations, and the number of matching unstable conformations

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Therefore, B12 deficiency should be excluded or treated before starting folic acid in patients with unexplained anaemia or neurological symptoms